Why responses to the same GRBM differ —
the gut ecosystem has the answer

I define the change before and after GRBM intake with an observational index, the Microbiome Recovery Resilience Index (MRI). It is not about how much of a particular bacterium there is, but an integrated index of whether the gut ecosystem is shifting from an "activation state" dominated by Clostridium to a "recovery state" dominated by Vital Probiotics.

• VPI · Vital Probiotics IndexThe relative share and diversity of lactic acid bacteria — Lactobacillus and Lactococcus, Leuconostoc, Pediococcus, Weissella and others
• LDS · Lactobacillus Diversity ScoreHow many Lactobacillus-related taxa are detected — ten or more is used as the first criterion of functional diversity
• DBI · Dysbiosis Burden IndexThe share of groups that can create resistant or inflammatory ecosystems: Clostridium, Enterobacteriaceae, Helicobacter, Romboutsia and excessive single dominants
• OASI · Organic Acid Switch IndexThe degree of shift from butyrate-centred metabolism to acetate and lactate–acetate compound organic-acid metabolism
• HFRS · Host Functional Recovery ScorePerson-centred functional recovery: weight, appetite, pain, sleep, fatigue, exercise capacity, strength, neuropsychiatric symptoms and return to social life

Most microbes have both a beneficial and a harmful side. When the share of lactobacilli in the small intestine rises, large-intestine microbes tend more often to express beneficial traits; in the opposite case, harmful traits. Rather than fixing bacteria as good or bad by name, function is interpreted by the dominance structure and metabolic direction of the whole ecosystem.

Before VPMI is applied, many microbial groups are mixed inside a plant; after it, the Lactobacillus group comes to dominate at 90% or more. GRBM manufacturing is a microbiome-engineering process that turns the plant's internal microbial ecosystem into a lactobacilli-centred structure.

Because lactobacilli differentiate into species fairly freely through horizontal gene transfer, I see clear limits in a single-strain approach. Just as research suggests a mother's gut microbe–metabolome network can influence fetal development and immune and metabolic programming, Vital Probiotics are closer to the concept of a metabolic network that supports life activity.

I see autoimmune disease as a chronic immune malfunction, in which gut-ecosystem imbalance, the accumulation of ageing metabolites inside cells, deposits of waste in blood and lymph vessels, weakened cell-to-cell signalling and abnormal regulation of gene expression pile on top of immune misrecognition and metabolic abnormality at the cellular level. So the aim is not to force immunity down, but to create the physiological conditions in which cells and the immune system can leave the state of over-activation and misrecognition and work normally again.

1. 01
   Bone-marrow activation

   As T-cell re-education begins, a temporary deep, anaemia-like fatigue can appear

2. 02
   Stronger abdominal-aortic pulsation

   Classified as a signal that the central circulatory axis is reactivating

3. 03
   Thymic reactivation

   The thymus, which makes and selects T cells, goes back to work and re-education begins in earnest

4. 04
   Deep recovery sleep

   Sleep that appears as the whole body enters recovery mode

5. 05
   Rising peripheral temperature

   A recovery heat response in which skin temperature rises about 0.8–1.2 °C while ear temperature stays the same

6. 06
   Treg re-education complete

   The immune system shifts to a state in which it recognizes its own tissues normally again

In observed cases of severe Crohn's disease and severe psoriasis, a general metabolome response appeared for about 4–8 weeks, then the sequence above was observed in the later stage, and symptom resolution and return to daily life were reported around week 12. Among participants in the early 2018 observations, some have reported no relapse as of 2026.