02 / HOLOBIONT THEORY
When the three move as one,
the "healthy self" appears
The genome is the blueprint, the microbiome our neighbors inside, and the metabolome the language all three share. And within the single word "metabolome" there are two entirely different things.
In plain words
An adult body holds about 30 trillion human cells and about 38 trillion microbes. A human is not made of human cells alone. Seeing the host and all its microbes as one unit of life is the concept of the Holobiont, which is established in science.
GRBM adds the plants we eat every day. It sees people, microbes and plants as one ecosystem talking in a common language: metabolites.
Genome (blueprint), microbiome (neighbors), metabolome (language). When the three move separately the body's balance wavers; the more they overlap, the clearer the "healthy self" becomes. I call that central place the hologenome.
The same "metabolome" — two entirely different things
Ordinary metabolites, produced by digesting food, need enzymes before cells can use them, and the butyrate pathway they use to produce energy leaves aging substances such as reactive oxygen species. The GRBM metabolome, by contrast, has been pre-metabolized by plants and beneficial microbes and even carries genetic information, so it is absorbed without digestion and used by cells without enzymes. When producing energy it follows the lactate–acetate pathway and leaves no separate aging substances.
Read moreCloseHow conventional medicine and GRBM see the three elements, and the investment view
The concepts, one by one
| Concept | In one line |
|---|---|
| Holobiont | One person is one ecosystem in which human and microbes live together |
| Genome | The blueprint from our parents — it needs good materials to be expressed well. GRBM supplies them as Metabolomed Proteins |
| Microbiome | Our neighbors inside — research has mostly studied stool (the large intestine), but GRBM focuses on the jejunum, the upper small intestine where nutrients are absorbed |
| Metabolome | The language the three share — the GRBM metabolome is bound with genetic material such as External miRNA and carries genetic information |
| Hologenome | Host and microbial genomes plus the metabolome — the "healthy self" that appears fully when the three are expressed in balance |
Conventional medicine and GRBM — the same three, a different place
| Item | Conventional medicine | GRBM | What changes |
|---|---|---|---|
| Metabolome | The sum of substances the body makes | The sum of substances + exchanged genetic material | Metabolites become carriers of genetic information |
| Genome | Exon–telomere, irreversible aging | Intron–telomere, reversible aging response | From aging that cannot be undone to aging that can |
| Microbiome | Large-intestine centered (stool samples) | Small intestine, especially the jejunum | The upper small intestine, where nutrients are absorbed, is the main stage |
Most nutrients are absorbed in the small intestine, yet microbiome research has relied mainly on stool samples, leaving the small-intestinal microbiome relatively unexplored. GRBM sees exactly this gap as the key interface of the human holobiont.
From an investment perspective
The input that moves all three elements at once is the metabolome, and VPMI is the process that makes a metabolome carrying genetic information. Technologies that directly alter genes face high regulatory and safety barriers. GRBM reaches the three elements through metabolites — the body's own language — without altering genes. That is why it can start immediately in the widest market: bio-food.
Literature: hologenome theory (FEMS Microbiology Reviews, 2008), ten principles of holobionts (PLoS Biology, 2015), estimates of human and bacterial cell numbers (PLoS Biology, 2016). Interpretation: source — the developer's (Wooyoung Nam's) research.
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